菲利普·戈莱特的两篇综述分别是P. Goelet, V. F. Castellucci, S. Schacher, and E. R. Kandel, “The long and short of long-term memory—a molecular framework,” Nature322 (1986): 419–22; 和P. Goelet and E. R. Kandel, “Tracking the flow of learned information from membrane receptors to genome,” Trends Neurosci. 9 (1986): 472–99.
我们与钱永健合作关于依赖环腺苷酸的蛋白激酶的迁移实验，他是加州大学圣迭戈分校的霍华德·休斯研究员，开发了一种方法可以让依赖环腺苷酸的蛋白激酶移动到细胞核的过程可视化。这项研究的论文信息是B. J. Bacskai, B. Hochner, M. Mahaut-Smith, S. R. Adams, B.-K. Kaang, E. R. Kandel, and R. Y. Tsien, “Spatially resolved dynamics of cAMP and protein kinase A subunits in Aplysiasensory neurons,” Science260 (1993): 222–26.
用于海兔神经元的组织培养方法是由山姆·沙克与我的学生斯蒂芬·雷波特、皮尔·希奥尔希奥·蒙塔洛罗和埃里克·普罗香斯基合作开发的。
CREB的学习相关可塑性的最初证据参见P. K. Dash, B. Hochner, and E. R. Kandel, “Injection of cAMP-responsive element into the nucleus of Aplysiasensory neurons blocks long-term facilitation,” Nature345 (1990): 718–21.
海兔体内的阻遏蛋白的发现参见D. Bartsch, M. Ghirardi, P. A. Skehel, K. A. Karl, S. P. Herder, M. Chen, C. H. Bailey, and E. R. Kandel, “AplysiaCREB-2 represses long-term facilitation: Relief of repression converts transient facilitation into long-term functional and structural change,” Cell83 (1995): 979–92.
对于果蝇记忆研究的新程式，参见T. Tully, T. Preat, S. C. Boynton, and M. Del Vecchio, “Genetic dissection of consolidated memory in Drosophila melanogaster,” Cell79 (1994): 35–47.
一些果蝇研究指出CREB阻遏蛋白在阻断短时记忆中所扮演的角色以及激活蛋白在习得性恐惧的记忆存储的增强过程中过度表达，参见J. C. P. Yin, J. S. Wallach, M. Del Vecchio, E. L. Wilder, H. Zhuo, W. G. Quinn, and T. Tully, “Induction of a dominant negative CREB transgene specifically blocks long-term memory in Drosophila,” Cell79 (1994): 49–58; J. C. P. Yin, M. Del Vecchio, H. Zhou, and T. Tully, “CREB as a memory modulator: Induced expression of a dCREB2activator isoform enhances long-term memory in Drosophila.” Cell81 (1995): 107–15.
对于蜜蜂中的CREB的证据，参见D. Eisenhardt, A. Friedrich, N. Stollhoff, U. Müller, H. Kress, and R. Menzel, “The AmCREB gene is an ortholog of the mammalian CREB/CREM family of transcription factors and encodes several splice variants in the honeybee brain,” Insect Molecular Biol. 12 (2003): 373–82.
CREB在小鼠习得性恐惧中的证据，参见P. W. Frankland, S. A. Josselyn, S. G. Anagnostaras et al., “Consolidation of CS and US representations in associative fear conditioning,” Hippocampus14 (2004): 557–69; 和S. Kida, S. A. Josselyn, S. P. de Ortiz et al., “CREB required for the stability of new and reactivated fear memories,” Nature Neurosci. 5 (2002): 348–55.
对于CREB在人类学习中的证据，参见J. M. Alarcon, G. Malleret, K. Touzani, S. Vronskaya, S. Ishii, E. R. Kandel, and A. Barco, “Chromatin acetylation, memory, and LTP are impaired in CBP+/–mice: A model for the cognitive deficit in Rubinstein-Taybi Syndrome and its amelioration,”Neuron42 (2004): 947–59.
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