[35]BLOCH K.The biological synthesis of cholesterol[J].Science，1965，150（3692）：19-28.
[36]BROWN M S, DANA S E, GOLDSTEIN J L.Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts by lipoproteins[J].Proceedings of the National Academy of Sciences，1973，70（7）：2162-2166.
[37]GOLDSTEIN J L, BROWN M S.Familial hypercholesterolemia：identification of a defect in the regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity associated with overproduction of cholesterol[J].Proceedings of the National Academy of Sciences，1973，70（10）：2804-2808.
[38]BROWN M S, GOLDSTEIN J L.Familial hypercholesterolemia：Defective binding of lipoproteins to cultured fibroblasts associated with impaired regulation of 3-hydroxy-3-methylglutaryl coenzyme a reductase activity[J].Proceedings of the National Academy of Sciences，1974，71（3）：788-792.
[39]ENDO A, KURODA M, TANZAWA K.Competitive inhibition of 3-hydroxy-3-methylglutaryl coenzyme a reductase by ML-236A and ML-236B fungal metabolites, having hypocholesterolemic activity[J].FEBS Letters，1976，72（2）：323-326.
[40]ENDO A, KURODA M, TSUJITA Y.ML-236A, ML-236B, and ML-236C, new inhibitors of cholesterogenesis produced by Penicillium citrinium[J].J Antibiot（Tokyo），1976，29（12）：1346-1348.
[41]GOLDSTEIN L J, BROWN S M.The low-density lipoprotein pathway and its relation to atherosclerosis[J].Annual Review of Biochemistry，1977，46（1）：897-930.
[42]BROWN M S, FAUST J R, GOLDSTEIN J L, et al.Induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity inhuman fibroblasts incubated with compactin（ML-236B），a competitive inhibitor of the reductase[J].Journal of Biological Chemistry，1978，253（4）：1121-1128.
[43]HOBBS H H, RUSSELL D W, BROWN M S, et al.The LDL receptor locus in familial hypercholesterolemia：mutational analysis of a membrane protein[J].Annual Review of Genetics，1990，24（1）：133-170.
[44]ABIFADEL M, et al.Mutations in PCSK9 cause autosomal dominant hyperchole sterolemia[J].Nature Genetics，2003，34（2）：154-156.
[45]MAXWELL K N, BRESLOW J L.Adenoviral-mediated expression of Pcsk 9 in mice results in a low-density lipoprotein receptor knockout phenotype[J].Proceedings of the National Academy of Sciences of the United States of America，2004，101（18）：7100-7105.
[46]COHEN J, et al.Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9[J].Nature Genetics，2005，37（2）：161-165.
[47]FOX K A, STEG P, EAGLE K A, et al.Decline in rates of death and heart failure in acute coronarysyndromes，1999-2006[J].JAMA，2007，297（17）：1892-1900.
[48]STOSSEL T P.The Discovery of Statins[J].Cell，2008，134（6）：903-905.
[49]SCHEKMAN R.Discovery of the cellular and molecular basis of cholesterol control[J].Proceedings of the National Academy of Sciences，2013，110（37）：14833-14836.
[50]AJUFO E, RADER D J.Recent advances in the pharmacological management of hypercholes-terolaemia[J].The Lancet Diabetes&Endocrinology，2016，4（5）：436-446.
